Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains.

نویسندگان

  • M Speitling
  • P Nattewan
  • K Yazawa
  • Y Mikami
  • I Grün-Wollny
  • M Ritzau
  • H Laatsch
  • U Gräfe
چکیده

New anthracycline antibiotics 3'-O-demethyl mutactimycin (3) and 4-O,3'-O-didemethyl mutactimycin (4) were isolated from two actinomycetes strains, Nocardia transvalensis and Streptomyces sp. GW 60/1571. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy. Antibiotic 3 displayed moderate antimicrobial activity against Gram-positive bacteria and cytotoxicity against P388, L1210 and HeLa tumor cells (IC50; 9.6, >25 and 20 microg/ml, respectively).

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THE JOURNAL OF ANTIBIOTICS Demethyl mutactimycins, new anthracycline antibiotics from Nocardia and Streptomyces strains

+ Institute of Organic Chemistry, Tammannstraße 2, D-37077 Göttingen, Germany ++ Division of Clinical Mycology, National Institute of Health, Department of Medical Science, Nonthaburi, Thailand +++ Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-City, Chiba (260), Japan ‡ Labor für Bodenmikrobiologie, Burggarten 9, D-35102 Lohra-Kir...

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 51 8  شماره 

صفحات  -

تاریخ انتشار 1998